IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer

<div>IMCA inhibited the mTOR/P70S6K activity through phosphorylating AMPK. DLD-1 (a) and HCT116 (b) cells were treated with 50 <i>μ</i>M IMCA for 48 h, and the protein expression was assessed by Western blot. The intensities of the p-AMPK, p-mTOR, and p-P70S6K bands were quantified by densitometry analyses and normalized by the amount of AMPK, mTOR, and P70S6K in DLD-1 (c) and HCT116 (d) cells, respectively (<span class="nowrap"><svg height="8.55521pt" id="M43" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 27.8368 8.55521" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer 