Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Figure 3

Surface map of Keap1 protein (a) and chemical structure of (S,R,S) (b). The colored residues represent the active site of Keap1 which is involved directly in the interaction with the inhibitor (S,R,S) (PDB ID: 4l7b) and include Y334, S363, R380, N414, R415, S508, S555, Y572, and S602.

(a)

(b)