Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Figure 6

Docking models of fraxin, wedelolactone, glycycoumarin, and hydrangenol with Keap1. All the compounds are rich with polar groups and form hydrogen bonds with the polar, negatively and positively charged amino acids in the vicinity of the active site of Keap1.