Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

Table 4

Liver glycogen content, G-6-Pase, and glycogen phosphorylase activities in normal, diabetic control, and diabetic groups treated with C. reticulata fruit peel extract, hesperidin, and quercetin.

Parameter groups	Glycogen (mg/g tissue)	% change	G-6-Pase (mg Pi liberated/g tissue/hour)	% change	Glycogen phosphorylase activity (mg Pi liberated/g tissue/hr)	% change
Normal	22.02 ± 2.34^a	—	18.89 ± 1.61^c	—	12.35 ± 0.43^c	—
Diabetic control	8.12 ± 0.80^c	-63.12	59.92 ± 2.72^a	217.20	25.97 ± 0.78^a	11.02
Diabetic treated with fruit peel extract	14.03 ± 0.72^b	72.78	35.30 ± 1.81^b	-41.08	15.65 ± 0.047^b	-39.73
Diabetic treated with hesperidin	15.81 ± 0.85^b	94.70	36.10 ± 1.82^b	-39.75	16.03 ± 0.67^b	-38.27
Diabetic treated with quercetin	13.07 ± 0.50^b	60.96	33.51 ± 2.31^b	-44.07	15.70 ± 0.35^b	-39.54
-probability
LSD at 5% level	3.60		6.11		1.65
LSD at 1% level	4.87		8.27		2.24

Data are represented as of six rats. Means which have different superscript letters are significantly different at . Percentage changes were calculated by comparing diabetic control with normal and diabetic treated groups with diabetic control.