Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

Table 8

Liver oxidative stress and antioxidant defense markers in normal, diabetic control, and diabetic groups treated with C. reticulata fruit peel extract, hesperidin, and quercetin.

Parameter groups	LPO (nmole/MDA/100 mg tissue)	GSH (nmole/100 mg tissue)	GPx (mU/100 mg tissue)	GST (U/100 mg tissue)	SOD (U/mg tissue)
Normal	25.13 ± 0.68^c	50.03 ± 2.6^a	183.06 ± 1.7^a	160.43 ± 1.73^a	31.80 ± 1.97^a
Diabetic control	56.82 ± 1.05^a	21.13 ± 1.2^c	113.97 ± 2.5^d	83.11 ± 3.28^c	17.43 ± 0.92^c
Diabetic treated with fruit peel extract	39.09 ± 1.67^b	32.33 ± 0.91^b	153.66 ± 2.9^b	116.94 ± 4.97^b	24.98 ± 1.03^b
Diabetic treated with hesperidin	36.39 ± 2.07^b	32.70 ± 1.8^b	136.54 ± 3.25^c	112.77 ± 2.85^b	23.75 ± 1.44^b
Diabetic treated with quercetin	36.31 ± 2.16^b	33.14 ± 1.9^b	138.26 ± 2.60^c	125.14 ± 4.18^b	26.79 ± 1.57^b
-probability
LSD at 5% level	4.765	5.35	9.31	10.44	4.39
LSD at 1% level	6.447	7.24	12.59	14.12	5.95

Data are represented as of six rats. Means which have different superscript letters are significantly different at . Percentage changes were calculated by comparing diabetic control with normal and diabetic treated groups with diabetic control.