Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress

Figure 6

Metformin increased the expressions of Sirt1, Nrf2, and TXNIP in glyoxal-treated ARPE-19 cells. Glyoxal-induced ARPE-19 cells were cotreated with or without metformin (0.1 mM) for 24 h. Western blot and the quantification of Sirt1 (a), Nrf2 (b), and TXNIP (c). Data are expressed as the ( in (a), in (b), and in (c), versus glyoxal group). N: normal control; G: glyoxal-treated group; G+M: glyoxal and metformin cotreated group.

(a)

(b)

(c)