Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress

Figure 8

Metformin maintains the integrity of tight junctions of RPE cells in SI-treated rats. ZO-1 immunostaining (green) in RBCCs was examined at 1 day and 3 days after SI injection with or without intraperitoneal (a) or intravitreal (b) injections of metformin. N: intraperitoneal injections of normal saline (a) or vehicle (b); NS: intravitreal injections of normal saline; SI: sodium iodate-injection group; SI+Met: sodium iodate and metformin cotreatment group. Scale bar, 25 μm.

(a)

(b)