Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway

Figure 8

Expression of mitophagy-associated proteins, Keap1 and Nrf2, is regulated by rhSTC1 in rat kidney. Rats were treated as mentioned above. (a, b) Western blot was used to detect the expression of mitophagy-associated proteins, Keap1 and Nrf2 (). (c–j) Quantification of average Western blot band intensities. (k) Kidney sections from the mentioned groups were stained with PINK1, Parkin, LC3II, P62, Nrf2, and Keap1 antibodies for IHC analysis (magnification, ×400). Values were presented as . , compared with the control group. ^#, compared with the CI-AKI group.

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