Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration

Figure 3

UVB irradiation activates the RPE cell’s antioxidant defense system and two signaling pathways, JAK/STAT and NOTCH signaling pathways. Melanin and LEDGF too act as a photoprotection against UVB. Inhibition of different protein expressions or the formation of ROS negates the damaging effect of UVB and increases cell viability.