Long-Term Treatment with Fluvoxamine Decreases Nonmotor Symptoms and Dopamine Depletion in a Postnatal Stress Rat Model of Parkinson’s Disease

Figure 11

Effect of Fluvoxamine on dopamine in the (a) striatum, (b) prefrontal cortex, and (c) hippocampus of nonseparated (NS, NSF) and maternally separated (MS, MSF) rats at PND 76. In the striatum (a), a two-way ANOVA revealed a significant effect of maternal separation stress (, ; NS vs. MS, ; ^&NSF vs. MSF, , Tukey post hoc test) and an overall effect of Fluvoxamine treatment (, ; ^#NS vs. NSF, , Tukey post hoc test). /group. In the prefrontal cortex (b), a two-way ANOVA revealed an overall stress effect (, ; ^&NSF vs. MSF, , Tukey post hoc test). /group. In the hippocampus (c), a two-way ANOVA found no significant effect of Fluvoxamine treatment. /group. All data in this figure are expressed as mean ± SEM.

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