Long-Term Treatment with Fluvoxamine Decreases Nonmotor Symptoms and Dopamine Depletion in a Postnatal Stress Rat Model of Parkinson’s Disease

Figure 9

Effect of Fluvoxamine on malondialdehyde in the (a) striatum, (b) prefrontal cortex, and (c) hippocampus of nonseparated (NS, NSF) and maternally separated (MS, MSF) rats at PND 76. In the striatum (a), a two-way ANOVA revealed a significant interaction between stress and Fluvoxamine treatment (, ; ^&MS vs. MSF, ) and a stress effect (, ; NS vs. MS, , Tukey post hoc test). /group. In the prefrontal cortex (b), a two-way ANOVA revealed a significant interaction between stress and Fluvoxamine treatment (, ; ^#NS vs. NSF, ) and a stress effect (, ; NS vs. MS, , Tukey post hoc test). /group. In the hippocampus (c), a two-way ANOVA found no significant effect of Fluvoxamine treatment on MDA levels but an overall significant stress effect (, ). /group. All data in this figure are expressed as .

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