Inhibition of ERRα Aggravates Sepsis-Induced Acute Lung Injury in Rats via Provoking Inflammation and Oxidative Stress
Knockdown of ERRα enhanced LPS-induced mitochondrial ROS production in PMVECs. (a) Detection of mitochondrial ROS levels in PMVECs using a MitoSOX Red superoxide indicator. The red fluorescence indicated the presence of superoxide in the treated groups, whereas the control cells showed minimal fluorescence (upper panel). . The relative fluorescence intensity is compared among different groups (lower panel). (b) Representative blots of Sirt3 in the four groups (upper panel); quantitative results of Sirt3 (lower panel). The values are expressed as .a compared with the Ctr and shERRα group; b compared with the LPS group.
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