4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action

Figure 2

Sources of compound 4-mediated [Ca²⁺]_i signals in SH-SY5Y cells. The cells were stimulated with 100 μM compound 4 in the presence or absence of extracellular Ca²⁺ ions in medium. Typical traces of [Ca²⁺]_i responses in the presence (black) or absence (grey) of 1 mM Ca²⁺. The first arrow indicates the time of compound 4 addition. Subsequent addition of 1 mM Ca²⁺ as indicated (the second arrow) 870 s after stimulation with compound 4. Control is RFU level in Fura-4 NW loaded cells without stimulator. Values were presented in .