A Comprehensive Review on Schisandrin B and Its Biological Properties

Table 1

Antitumoral and molecular target of Sch B on several cancer cell lines.

Type of cancer	Cell lines	Targets	Effects	References
Colon	CACO2 HCT116	FAK ↓	Antiulcer	[48]
Prostate	DU145 LNCaP	PI3K, AKT, STA3, JAK2, CDK2, cyclin E ↓, p53, p21 ↑	Apoptosis; S phase arrest	[43]
Breast	MDA-MB-231, BT-549, MDA-MB-468, MCF-7	STAT3, DOX ↑, Survivin, TGF-β ↓	Apoptosis; Metastasis; Cell cycle arrest S phase; ROS production	[49–51]
Ovarian	A2780	DOX ↑; Survivin ↓	Apoptosis	[50]
Melanoma	B16F10	AKT ↓	Hyperpigmentation	[50]
Lung	A549	TGF-β1, Bcl-2, HIF-1, VEGF, MMP-9, MMP-2, cyclin D1, CDK6, CDK4 ↓, p53, p21 ↑	Cycle arrest at G2/M checkpoint and G0/G1; Apoptosis	[42, 52, 53]
Glioma	U251, U87	HOTAIR, p-Akt, p-Mtor MMP-9, ΔΨm ↓	Apoptosis	[54–56]
Cholangiocarcinoma		ΔΨm, cyclin D1, Bcl-2, CDK-4 ↓	G0/G1 phase arrest; Apoptosis	[57]
Gallbladder	GBC-SD and NOZ	Bax ↑ Bcl-2, NF-κB, cyclin D1 CDK-4 ↓	G0/G1 phase arrest; Apoptosis	[47]
Gastric	SCG-7901	Cyclin D1, mRNA ↓	G0/G1 phase arrest	[47]
Hepatoma	SMMC-7721	Hsp70 ↓	Apoptosis	[46]