Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 3 / Review Article
A Comprehensive Review on Schisandrin B and Its Biological Properties Table 3 Molecular mechanism of neuroprotection by Sch B.
Assay Organism tested Dose/conc. Mechanisms References Sch B prevents neuron from Alzheimer’s disease Mice 340, 290, 80, and 70 nM Inhibited glycogen synthase kinase-3β , therefore alleviating the cell injury induced by Aβ and the cognitive disorders in AD [65 ] Sch B prevents neurodegenerence induced by anxiety associated with oxidative stress Mice 30 mg/kg and 60 mg/kg Increase the activity of SOD, GSH, and Nrf2 and Keap1, along with suppression of ROS production [63 ] Sch B might improve Parkinson’s disease Mice 100 μ M Improve 6-OHDA-induced neural cell death and activated Nrf2 signaling pathways along with boosting the expression of miR-34a. Those protect from neurodegenerence [64 ] Sch B prevents cerebral ischemia Sprague-Dawley rats 10 and 30 mg/kg Inhibited the expression of proinflammatory factor (TNF-α and IL-1β ) as well as prevented the activation of MMP2/9 [60 ]