Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease

Figure 1

Metformin improves learning and memory impairment in APP/PS1 mice. (a) Escape latency of the five-day Morris water maze. (b) Time spent in the target quadrant in the Morris water maze. (c) Crossing times of the target platform in the Morris water maze. (d) Swimming speed in the Morris water maze. (e) Percentage of spontaneous alternation of Y-maze. Data represent the ( per group). , , and vs. WT; ^#, ^##, and ^### vs. APP/PS1.

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