Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease

Figure 5

Metformin decreases Aβ levels in APP/PS1 mice. The levels of (a) Aβ1-40 and (b) Aβ1-42 in the brain of APP/PS1 mice. ThT staining of the brain slides in APP/PS1 mice. Experimental values were expressed as the ( per group). , , and vs. WT; ^#, ^##, and ^### vs. APP/PS1. Bar: 100 μm.

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