Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease

Figure 6

Metformin has no effect on Aβ production and transportation-related genes in APP/PS1 mice. The activities of (a) α-, (b) β-, and (c) γ-secretases. The mRNA expressions of (d) ADAM10, (e) BACE1, (f) PS1, (g) LRP1, and (h) RAGE. Experimental values were expressed as the ( per group). , , and vs. WT; ^#, ^##, and ^### vs. APP/PS1.

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