Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease

Figure 7

Metformin activates AMPK and increases IDE in the brain of APP/PS1 mice. (a) The representative bands of p-AMPK, AMPK, IDE, NEP, and ACTB. Western blot analysis: (b) p-AMPK/AMPK, (c) IDE/ACTB, and (d) NEP/ACTB. Experimental values were expressed as the ( per group). , , and vs. WT; ^#, ^##, and ^### vs. APP/PS1.

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