Ginsenoside-Rg1 Rescues Stress-Induced Depression-Like Behaviors via Suppression of Oxidative Stress and Neural Inflammation in Rats

Figure 1

Ginsenoside-Rg1 ameliorates depression-like behaviors induced by CUMS exposure. (a) Pretreatment with ginsenoside-Rg1 (40 mg/kg) or fluoxetine (40 mg/kg) prevented the decreased consumption of sucrose solution in CUMS rats. (b) Pretreatment with ginsenoside-Rg1 or fluoxetine reversed the increases in immobility times of CUMS-exposed rats in the forced swim test. (c) Pretreatment with ginsenoside-Rg1 or fluoxetine reversed the decreases in swimming times of CUMS-exposed rats. (d) No statistically significant differences were obtained among the groups with regard to struggling times in the forced swim test. All values are presented as (). , compared to the control group; ^#, compared to the CUMS group. G-Rg1: ginsenoside-Rg1; FLX: fluoxetine; SPT: sucrose preference test; FST: forced swim test.

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