Ginsenoside-Rg1 Rescues Stress-Induced Depression-Like Behaviors via Suppression of Oxidative Stress and Neural Inflammation in Rats

<div>Ginsenoside-Rg1 suppresses glial activation and inflammatory cytokine expressions induced by CUMS exposure. (a) Immunofluorescence signals of Iba-1-positive microglial cells within the CA1 region. Scale bar is 50 <i>μ</i>m. (b) Immunofluorescence signals of GFAP-positive astrocytes within the CA1 region. Nuclei (blue) are stained with DAPI. Scale bar is 50 <i>μ</i>m. (c) Western blotting analysis of CD45 and CD11b protein expressions within each group. (d) RT-PCR assays of mRNA expression levels of IL-1<i>β</i>, TNF-<i>α</i>, and IFN-<i>γ</i> within each group. <svg height="8.8423pt" id="M56" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 32.2343 8.8423" width="32.2343pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 650Z"></path></g><g transform="matrix(.013,0,0,-0.013,14.542,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,25.805,0)"><path d="M137 343C167 482 260 545 321 574C357 591 397 603 429 609L423 641C382 634 335 622 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166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>,</span> compared to CUMS group. G-Rg1: ginsenoside-Rg1.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Ginsenoside-Rg1 Rescues Stress-Induced Depression-Like Behaviors via Suppression of Oxidative Stress and Neural Inflammation in Rats 