Oxidative Medicine and Cellular Longevity

Research Article

Redox States of Protein Cysteines in Pathways of Protein Turnover and Cytoskeleton Dynamics Are Changed with Aging and Reversed by Slc7a11 Restoration in Mouse Lung Fibroblasts

Table 4

GO-based cellular component analysis of proteins whose redox states were rescued by Slc7a11 overexpression in old fibroblasts. Fisher’s exact test values for all the items shown were lower than 0.05.
TermCount value-log10 ( value)
Extracellular exosome57<0.00123.688
Cell-cell adherens junction20<0.00114.949
Cytoplasm72<0.00114.704
Focal adhesion16<0.0019.092
Myelin sheath12<0.0018.558
Extracellular matrix13<0.0017.639
Cytosol28<0.0017.085
Intracellular ribonucleoprotein complex12<0.0016.291
Spliceosomal complex8<0.0015.304
Actin cytoskeleton9<0.0015.162
Cytoplasmic ribonucleoprotein granule5<0.0014.983
Cortical cytoskeleton5<0.0014.801
Stress fiber6<0.0014.700
Cytoskeleton18<0.0014.543
Perinuclear region of cytoplasm14<0.0014.457
Protein complex13<0.0014.216
Nucleus49<0.0014.123
Extracellular vesicle5<0.0014.002
Catalytic step 2 spliceosome6<0.0013.947
Proteasome complex5<0.0013.498