Hexachloronaphthalene Induces Mitochondrial-Dependent Neurotoxicity via a Mechanism of Enhanced Production of Reactive Oxygen Species

<div>The effect of PCN67 on PC12 cell differentiation. (a) Morphology of control and PCN67-treated differentiated PC12 cells photographed under an inverted phase microscope with a CCD camera. Scale bar 10 <i>μ</i>m. (b) Quantification of an average length of neurites. The cell protrusion was counted as neurite when its length was at least twice of cell diameter. (c) Quantification of an average number of neurite-forming cells. Cells with at least one visible neurite were considered. (d) The expression of neurofilament M (NF-M) and (e) neurofilament L (NF-L) was assessed by real-time PCR 72 h after PCN67 treatment. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Hexachloronaphthalene Induces Mitochondrial-Dependent Neurotoxicity via a Mechanism of Enhanced Production of Reactive Oxygen Species 