Research Article
Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure
Table 4
Prognostic value of clinical variables in Cox regression models.
| | Variables | Univariate | Multivariate | | HR (95% CI) | value | HR (95% CI) | value |
| | Age (each 10 years) | 1.59 (1.19, 2.12) | 0.001 | 1.13 (1.04, 1.22) | 0.002 | | Sex (female vs. male) | 1.16 (0.36, 3.76) | 0.80 | | | | BMI (each 1 kg/m2) | 1.09 (0.97, 1.64) | 0.27 | | | | Diabetes (yes vs. no) | 1.26 (0.97, 1.64) | 0.08 | 1.09 (0.90, 1.32) | 0.38 | | Smoking (yes vs. no) | 1.42 (0.39, 5.14) | 0.59 | | | | SBP (each 10 mmHg) | 1.00 (0.98, 1.03) | 0.85 | | | | NT-proBNP (each doubling) | 3.46 (1.39, 8.61) | 0.008 | 2.46 (1.05, 5.76) | 0.04 | | hs-CRP (each doubling) | 0.52 (0.23, 1.20) | 0.13 | | | | Sfrp2 (each doubling) | 1.25 (0.97, 1.64) | 0.09 | 1.18 (0.75, 1.86) | 0.47 | | ECV fraction (each doubling) | 1.79 (1.10, 2.91) | 0.02 | 1.68 (1.03, 2.74) | 0.04 | | LVEF (each doubling) | 0.49 (0.18, 1.33) | 0.16 | | | | eGFR (each doubling) | 0.42 (0.07, 2.42) | 0.33 | | |
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BMI: body mass index; CI: confidence interval; ECV: extracellular volume; eGFR: estimated glomerular filtration rate; HR: hazard ratio; LVEF: left ventricular ejection fraction; SBP: systolic blood pressure; hs-CRP: high-sensitivity C-reactive protein; NT-proBNP: N-terminal pro-B-type natriuretic peptide; SFRP2: secreted frizzled-related protein 2.
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