The Emerging Role of Senescence in Ocular Disease

Table 2

Ocular diseases associated with cellular senescence.

Diseases	Pathology	Therapeutic strategy	References
Age-related macular degeneration (AMD)	RPE senescence is associated with the pathology	N/A	[38, 86, 100]
Wet AMD	Macrophage senescence impairs cholesterol efflux and promotes neovascular AMD	N/A	[101]
Glaucoma	Senescent cells in the outflow pathway; retinal ganglion cell senescence	N/A	[90, 95, 102]
Experimental ocular hypertension	Senescence of retinal ganglion cells		[102]
Cataracts	Senescence in lens epithelial cells	NA	[103, 104]
Retinal microaneurysm	Neurons and blood vessels undergo cellular senescence in the retina	N/A	[42]
Fuchs endothelial dystrophy (FED)	Corneal endothelial cells (HCEC) senescence	Kojic acid	[105, 106]
Birdshot Uveitis	Shortening of telomere length in peripheral leukocytes.	N/A	[107]
Diabetic retinopathy	Endothelial cell senescence	N/A	[108–110]
Hyperglycemia-induced retinal microangiopathy	Senescence of the retinal microvasculature, RPE, and ganglion cell layer (GCL) type 1 diabetic rat model	N/A	[40]