Research Article
Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation
Figure 5
Modulation of caspase-8 activation by the miR-137-3p/CAPN-2 interaction after OGD/R. (a) Representative double immunofluorescence staining showing that p35 (green) and caspase-8 are predominantly localized in the cytoplasms of VSC4.1 neurons. . (b) Quantitative analysis of caspase-8 activity in VSC4.1 neurons of each treatment group. (c, d) Representative Western blots and protein quantification of p35, caspase-8, and caspase-3 in neurons. All samples were analyzed in triplicate, and the data are expressed as the . versus the control group; # versus the OGD/R group; & versus the OGD/R+miR-137 mimic group.
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