RNA and Oxidative Stress in Alzheimer’s Disease: Focus on microRNAs

Figure 2

A microRNA system mediates hormesis. As intensity of stressors increases, the number of differentially altered miRNAs increases, which is associated with a biphasic physiological phenotype. Under low doses of hormetic stress, a moderate increase in miRNAs is associated with an increase in physiological (beneficial) phenotype. However, under high doses of toxic stress, an excessive increase in miRNAs is associated with a decrease in physiological phenotype.