A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma

Figure 5

In vivo behavior, TAP-nanoemulsion administrated against metastatic melanoma in the lung of B16F10-bearing C57BL/6 mice. (a) Changes in mouse body weight after different treatments. (b) Mouse morbidity-free survival efficacy with different treatments following the vehicle control, tumor-only, and TAP-nanoemulsion groups. (c) The evaluations of organ weights observed from the three groups. (d) The mRNA expressions associated with the three groups in qRT-PCR assay. (e) TAP-nanoemulsion inhibited lung metastatic melanoma through induction of apoptosis-related proteins by Western blotting. We took α-tubulin as our experimental loading control. Data are representative of 3 experiments. Blue: blank control; yellow: tumor only; red: TAP-nanoemulsion treatment groups. as compared with the tumor-only group.

(a)

(b)

(c)

(d)

(e)