CIRBP Ameliorates Neuronal Amyloid Toxicity via Antioxidative and Antiapoptotic Pathways in Primary Cortical Neurons

Figure 2

CIRBP reversed iAβ-induced electrophysiological changes that are responsible for neuronal toxicity. (a, b) Resting membrane potentials (RMP) (a) and membrane capacitance (b) were recorded among different groups. vs. Ad-Con, vs. Ad-Con+iAβ. (c) Typical recordings of whole-cell K⁺ current in the Ad-Con, Ad-Con+iAβ, and Ad-CRIPB+iAβ groups by depolarizing the membrane from -70 mV to +70 mV from a holding potential at -70 mV with 10 mV increasing steps. (d) Current-voltage relationship of the peak K⁺ current density. vs. Ad-Con. (e) Voltage-dependent activation curve of K⁺ current showing there was no difference among different groups.

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