Dexmedetomidine Attenuates LPS-Induced Monocyte-Endothelial Adherence via Inhibiting Cx43/PKC-α/NOX2/ROS Signaling Pathway in Monocytes

Figure 5

The possible mechanism of dexmedetomidine attenuating monocyte-endothelial adherence. (1) Dexmedetomidine inhibits Cx43 expression in U937 monocytes; (2) with the downregulation of Cx43, PKC-α interacting with Cx43 carboxyl-terminal domain is also decreased; (3) inhibiting PKC-α attenuates NOX2 expression; (4) ROS production is inhibited; (5) the decrease of ROS level reduces VLA-4 and LFA-1 expression in U937 monocytes; and (6, 7) VLA-4 and LFA-1 expressions are both attenuated, and they could not adhere to VCAM-1 and ICAM-1 on HUVECs.