Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation

Figure 9

Effects of Nrf2 deficiency on GPS-mediated protein levels of Nrf2, NQO1, GCLC, GCLM, PPARα, and SREBP-1c. (a) WT and Nrf2^-/- mice were administered 80 mg/kg GPS for 1 h. After the mice were subjected to 500 mg/kg Ty for 12 h. Western blot examined of Nrf2, NQO1, GCLC, GCLM, PPARα, and SREBP-1c in WT and Nrf2^-/- mouse liver. (b–g) Quantification of Nrf2, NQO1, GCLC, GCLM, PPARα, and SREBP-1c was standardized to β-actin, respectively. All data are presented as (, number of mice in each group). ^## vs. control group; and vs. Ty-stimulated group.

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