Research Article
Network Pharmacology to Uncover the Biological Basis of Spleen Qi Deficiency Syndrome and Herbal Treatment
Table 2
Immune-related nodes in the SQD syndrome biomolecular network.
| | Top 20 biomolecules | Degree | Biological process and pathway |
| | PIK3R1 | 29 | T cell receptor signaling pathway | | MAPK14 | 27 | T cell receptor signaling pathway | | LCK | 27 | Natural killer cell-mediated bioactivity | | JUN | 26 | B cell receptor signaling pathway | | GRB2 | 25 | T cell receptor signaling pathway | | MAPK1 | 24 | T cell receptor signaling pathway | | AKT1 | 24 | B cell receptor signaling pathway | | MAPK8 | 24 | Helper T cell proliferation and differentiation | | SMAD3 | 23 | T cell receptor signaling pathway | | FYN | 23 | Natural killer cell-mediated bioactivity | | RELA | 23 | B cell receptor signaling pathway | | HSP90AA1 | 23 | Antigen processing and presentation | | CTNNB1 | 21 | Antigen processing and presentation | | SHC1 | 20 | Natural killer cell-mediated bioactivity | | TGFBR1 | 20 | Helper T cell proliferation and differentiation | | JAK2 | 17 | Helper T cell proliferation and differentiation | | FOS | 17 | B cell receptor signaling pathway | | MAP3K7 | 17 | B cell receptor signaling pathway | | NFKB1 | 17 | Leukocyte transendothelial migration | | MAPK3 | 16 | T cell receptor signaling pathway |
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