Memory-Enhancing Effect of a Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with Metabolic Syndrome

Table 1

The effect of PMG on acetylcholinesterase activity and oxidative stress alterations in the prefrontal cortex.

Treatment groups	AChE (nmol/min·mg protein)	MDA (ng/mg protein)	SOD (units/mg protein)	CAT (units/mg protein)	GSH-Px (units/mg protein)
ND+vehicle
HCHF+sham+vehicle
HCHF+MCAO+vehicle	^aaa,bbb	^aaa,bbb	^aa,bb	^aa,bb	^aaa,bbb
HCHF+MCAO+vitamin C
HCHF+MCAO+donepezil
HCHF+MCAO+PMG50
HCHF+MCAO+PMG100
HCHF+MCAO+PMG200

Data are presented as (/group). ^aa value < 0.01 and ^aaa value < 0.001; compared between control rats which received a normal diet and vehicle and MetS+MCAO rats which received HCHF, MCAO, and vehicle. ^bb value < 0.01 and ^bbb value < 0.001; compared between sham rats which received HCHF, sham operation, and vehicle and MetS+MCAO rats which received HCHF, MCAO, and vehicle. value < 0.05, value < 0.01, and value < 0.001; compared to MetS+MCAO rats which received HCHF, MCAO, and vehicle. ND: normal diet; HCHF: high-carbohydrate high-fat diet; MetS: metabolic syndrome; MCAO: middle cerebral artery occlusion; Vitamin C: vitamin C at a dose of 250 mg·kg^-1 BW; Donepezil: donepezil at a dose of 3 mg·kg^-1 BW; PMG50, PMG100, and PMG200: the phytosomes containing the combined extract of mulberry fruit and ginger at doses of 50, 100, and 200 mg·kg^-1 BW, respectively.