Research Article
Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease
Table 3
Performance summary corresponding with the results obtained for all Random Forest models.
| Enzyme | Validation | Accuracy | Sensitivity | Specificity | PPV | NPV | MCC |
| JNK-3 | Test | 0.89 | 0.91 | 0.87 | 0.86 | 0.91 | 0.78 | Cross | 0.83 | 0.85 | 0.82 | 0.81 | 0.85 | 0.67 | PTP1B | Test | 0.81 | 0.81 | 0.81 | 0.82 | 0.80 | 0.62 | Cross | 0.82 | 0.82 | 0.82 | 0.83 | 0.81 | 0.64 | NFR2 | Test | 0.76 | 0.75 | 0.76 | 0.86 | 0.61 | 0.50 | Cross | 0.73 | 0.78 | 0.63 | 0.80 | 0.60 | 0.41 | NOX1 | Test | 0.82 | 0.76 | 0.91 | 0.92 | 0.73 | 0.67 | Cross | 0.80 | 0.89 | 0.66 | 0.92 | 0.73 | 0.58 | PDE5 | Test | 0.87 | 0.9 | 0.84 | 0.85 | 0.9 | 0.75 | Cross | 0.86 | 0.88 | 0.85 | 0.85 | 0.87 | 0.73 | COX2 | Test | 0.78 | 0.83 | 0.71 | 0.77 | 0.78 | 0.55 | Cross | 0.76 | 0.81 | 0.7 | 0.76 | 0.76 | 0.52 | iNOS | Test | 0.81 | 0.87 | 0.74 | 0.78 | 0.84 | 0.62 | Cross | 0.8 | 0.85 | 0.74 | 0.78 | 0.82 | 0.60 |
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