Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 1

Research Article

Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and Their Prospective Roles in Kidney Disease

Table 1

Summary of the studies of MAMs’ involvement in kidney disease.

Mouse modelCell typesChanges in MAMsKidney outcomesRef.

Adriamycin-induced nephropathyPodocytesIncreasedPromoting podocyte apoptosis and increasing proteinuria[126]
Streptozocin- (STZ-) induced diabetic miceTubular cellsDecreasedPromoting tubule apoptosis and accelerating kidney damage[74]
Db/db micePodocytesIncreasedPromoting mitochondrial Ca2+ overload and dysfunction, and exacerbating renal damage[50]

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