Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 1

Research Article

New Synthetic 3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPKα in SCA17 Cell Models

Figure 1

Test compounds and cytotoxicity. (a) Structure, formula, and molecular weight of licochalcone A, LM-004, LM-006, LM-016, LM-026, and LM-031. (b) Cytotoxicity of test compounds (0.1−100 μM) in uninduced TBP/Q79-GFP 293 and SH-SY5Y cells using the MTT assay (). To normalize, the relative untreated cell viability was set as 100%. Values shown are the IC50 values.
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