Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis

Figure 3

Fucoidan activates autophagy in ApoE-/- mice. (a) Detection of autophagosomes in unstable carotid atherosclerotic plaques by TEM. . (b, c) Representative western blot analysis of the protein expression levels of p62 and LC3 in the carotid arteries. All data are representative of three independent experiments. (d, e) Immunohistochemical analysis of p62 in carotid atherosclerotic plaques. Autophagosomes were indicated by arrows. . Data are shown as the (). vs. control; ^# vs. model.

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