Natural Exogenous Antioxidant Defense against Changes in Human Skin Fibroblast Proteome Disturbed by UVA Radiation

Figure 6

Two-dimensional hierarchical clustering heat map of the significantly different proteins ( value < 0.05) from the 3D cultured fibroblasts following exposure to UVA (20 J/cm²) (a) and treated separately with rutin (25 μM) (b) or ascorbic acid (100 μM) (c) as well as both compounds together (d). For the creation of heat map A, only the top 50 of significant proteins were used, while all significant proteins were used in heat maps (b–d). Abbreviations: Asc: ascorbic acid; Ctr: control; Rut: rutin. Functions: (A) catalytic activity; (B) transcription/translation regulator; (C) protein degradation regulator; (D) signaling molecule; (E) inflammation regulator; (F) antioxidant activity; (G) binding activity.