Research Article
Neochamaejasmin A Induces Mitochondrial-Mediated Apoptosis in Human Hepatoma Cells via ROS-Dependent Activation of the ERK1/2/JNK Signaling Pathway
Figure 7
JNK and ERK1/2 are involved in HepG2 cell apoptosis induced by NCA. HepG2 cells were pretreated with 10 μM SP600125 or PD0325901 for 1 h and then treated with 73.7 μM NCA for 48 h. (a, b) The apoptotic rate was examined flow cytometry. (c, d) The protein levels of Bax, cleaved caspase-3, and cytoplasmic cytochrome c were analyzed by Western blot. and , compared with the control group.
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