Review Article
Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer
Table 3
Characterization of omeprazole studies in relation to toxicogenetic effect, oxidative damage, and cytotoxicity.
| | Parameters | Clinical % () | Nonclinical % | | In vitro () | In vivo () |
| | Toxicogenetic effect | | Mutagenicity | 5.3 | — | — | | Interaction with catalase | — | 9.1 | — | | Activation of AhR | — | 9.1 | 13.3 | | Not reported | 94.7 | 81.8 | 86.7 | | Oxidative damage | | Oxidation of thiols | 10.4 | 18.2 | 20 | | Inhibition of cysteine interaction | — | 9.1 | — | | Interaction and oxidation of cysteine residues | — | 9.1 | — | | ROS induction | 89.5 | 63.6 | 80 | | Cytotoxicity | | Oxidation of thiols | 50.5 | 18.2 | 20 | | Oxidation of cysteine residues | 49.5 | 18.2 | - | | ROS induction | — | 45.4 | 80 |
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AhR: aryl hydrocarbon receptors; ROS: reactive oxygen species. Chi-square test . |
