Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy
Sal promoted the recovery of motor function in mice and reduced the loss of motor neurons in the anterior horn after SCIRI. (a) Schematic diagram of the experimental design. (A) The chemical structure of Sal. (b) BMS scores at different time points following SCIRI. (c) The inclined plate test at different time points after SCIRI. (d) Representative paw prints at 14 days after SCIRI and quantitative analysis of step length of mice. Blue: paw print of the front paw; red: paw print of the hind paw. (e) Nissl staining indicating the number of motor neurons in the anterior horn of the spinal cord in each group. Scale bar, 100 μm. , compared to the SCIRI group; #, compared with the Sal (50 mg/kg/d) group. All values in this figure were presented as (),.
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