Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2

Figure 6

FSTL1 overexpression attenuated DOX-induced damage in vitro. (a, b) Nrf2 expression and Nrf2 activity in NRCMs (). (c) Nrf2 expression after siRNA infection (). (d) ROS production in NRCMs (). (e) The mRNA levels of SOD1 in NRCMs (). (f) The level of 4-HNE in NRCMs (). (g, h) Caspase 3 activity and LDH release (). (i) Cell viability (). . For (c), the data were analyzed using two-tailed Student’s -tests. For the others, the data were analyzed using one-way ANOVA, followed by Tukey’s post hoc analysis.

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