Research Article
Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease
Table 1
25 differentially expressed metabolites in serum and brain tissue.
| Compounds | Class | Serum | Brain | VIP | value | Trend | VIP | value | Trend |
| (5-L-Glutamyl)-L-amino acid | Amino acid metabolomics | 1.50329 | 0.0308 | Up | 1.016439 | 0.0183 | Up | Dulcitol | Carbohydrate metabolomics | 1.508731 | 0.0283 | Down | 1.931532 | <0.0001 | Down | Phenyllactate (Pla) | Organic acid and its derivatives | 2.503092 | <0.0001 | Down | 1.087977 | 0.0039 | Down | 9,10-DiHOME [(±)9,10-dihydroxy-12Z-octadecenoic acid] | Oxidized lipid | 1.826174 | 0.0067 | Up | 1.367845 | 0.0027 | Down | Cis-11,14,17-eicosatrienoic acid (C20:3) | Lipids fatty acids | 1.56911 | 0.0203 | Up | 2.024657 | <0.0001 | Down | (S)-(-)-2-Hydroxyisocaproic acid | Organic acid and its derivatives | 2.884665 | <0.0001 | Down | 1.71456 | 0.0002 | Down | Neopterin | Pteridines and derivatives | 1.910464 | 0.005 | Up | 2.007469 | <0.0001 | Down | 4-Ethylbenzoic acid | Benzene and substituted derivatives | 1.945169 | 0.0041 | Up | 1.970055 | <0.0001 | Down | 2-Picolinic acid | Pyridine and pyridine derivatives | 1.332943 | 0.0481 | Down | 1.325756 | 0.0032 | Down | Adenine | Nucleotide metabolomics | 1.548782 | 0.0288 | Down | 1.323111 | 0.0064 | Down | D-Glucono-1,5-lactone | Carbohydrate metabolomics | 2.446655 | <0.0001 | Up | 1.465692 | 0.0013 | Up | Nicotinic acid | CoOthersEnzyme factor & vitamin | 1.906224 | 0.0066 | Down | 1.084725 | 0.0124 | Down | 1-Naphthylacetic acid | Organic acid and its derivatives | 1.490897 | 0.0181 | Down | 1.612702 | 0.0008 | Up | Cholesterol | Lipids | 2.80908 | <0.0001 | Up | 2.226335 | <0.0001 | Up | Hexadecanamide | Lipids fatty acids | 1.291087 | 0.0274 | Up | 1.304757 | 0.0301 | Up | Triethyl phosphate | Organic acid and its derivatives | 2.413266 | 0.0001 | Down | 2.140886 | <0.0001 | Down | 1,2-Dichloroethane | Hydrocarbon derivative | 2.825226 | <0.0001 | Up | 1.319369 | 0.0062 | Up | (E)-2-Octen-1-ol | Alcohol | 1.769306 | 0.0077 | Down | 1.246376 | 0.0071 | Down | Barbituric acid | Heterocyclic compound | 1.554395 | 0.0277 | Down | 1.196766 | 0.0072 | Down | Carene | Heterocyclic compound | 2.232867 | 0.0004 | Up | 2.123199 | <0.0001 | Down | Hexyl acetate | Fatty acyls | 1.79975 | 0.0087 | Up | 1.554381 | 0.0003 | Down | 2,4,6-Trimethylphenol | Phenols and its derivatives | 2.660509 | <0.0001 | Down | 1.641595 | 0.0002 | Down | Terpinolene | Terpenoid | 2.707682 | <0.0001 | Down | 1.474065 | 0.0004 | Down | Octanal | Aldehyde | 1.481981 | 0.0278 | Down | 1.129016 | 0.0196 | Down | Naphthalene | Benzene and substituted derivatives | 1.663639 | 0.0121 | Down | 1.255286 | 0.0057 | Down |
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The name of compounds, class, VIP, value, and trend of metabolites were shown in the table. |