Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease

Table 1

25 differentially expressed metabolites in serum and brain tissue.

Compounds	Class	Serum			Brain
		VIP	value	Trend	VIP	value	Trend
(5-L-Glutamyl)-L-amino acid	Amino acid metabolomics	1.50329	0.0308	Up	1.016439	0.0183	Up
Dulcitol	Carbohydrate metabolomics	1.508731	0.0283	Down	1.931532	<0.0001	Down
Phenyllactate (Pla)	Organic acid and its derivatives	2.503092	<0.0001	Down	1.087977	0.0039	Down
9,10-DiHOME [(±)9,10-dihydroxy-12Z-octadecenoic acid]	Oxidized lipid	1.826174	0.0067	Up	1.367845	0.0027	Down
Cis-11,14,17-eicosatrienoic acid (C20:3)	Lipids fatty acids	1.56911	0.0203	Up	2.024657	<0.0001	Down
(S)-(-)-2-Hydroxyisocaproic acid	Organic acid and its derivatives	2.884665	<0.0001	Down	1.71456	0.0002	Down
Neopterin	Pteridines and derivatives	1.910464	0.005	Up	2.007469	<0.0001	Down
4-Ethylbenzoic acid	Benzene and substituted derivatives	1.945169	0.0041	Up	1.970055	<0.0001	Down
2-Picolinic acid	Pyridine and pyridine derivatives	1.332943	0.0481	Down	1.325756	0.0032	Down
Adenine	Nucleotide metabolomics	1.548782	0.0288	Down	1.323111	0.0064	Down
D-Glucono-1,5-lactone	Carbohydrate metabolomics	2.446655	<0.0001	Up	1.465692	0.0013	Up
Nicotinic acid	CoOthersEnzyme factor & vitamin	1.906224	0.0066	Down	1.084725	0.0124	Down
1-Naphthylacetic acid	Organic acid and its derivatives	1.490897	0.0181	Down	1.612702	0.0008	Up
Cholesterol	Lipids	2.80908	<0.0001	Up	2.226335	<0.0001	Up
Hexadecanamide	Lipids fatty acids	1.291087	0.0274	Up	1.304757	0.0301	Up
Triethyl phosphate	Organic acid and its derivatives	2.413266	0.0001	Down	2.140886	<0.0001	Down
1,2-Dichloroethane	Hydrocarbon derivative	2.825226	<0.0001	Up	1.319369	0.0062	Up
(E)-2-Octen-1-ol	Alcohol	1.769306	0.0077	Down	1.246376	0.0071	Down
Barbituric acid	Heterocyclic compound	1.554395	0.0277	Down	1.196766	0.0072	Down
Carene	Heterocyclic compound	2.232867	0.0004	Up	2.123199	<0.0001	Down
Hexyl acetate	Fatty acyls	1.79975	0.0087	Up	1.554381	0.0003	Down
2,4,6-Trimethylphenol	Phenols and its derivatives	2.660509	<0.0001	Down	1.641595	0.0002	Down
Terpinolene	Terpenoid	2.707682	<0.0001	Down	1.474065	0.0004	Down
Octanal	Aldehyde	1.481981	0.0278	Down	1.129016	0.0196	Down
Naphthalene	Benzene and substituted derivatives	1.663639	0.0121	Down	1.255286	0.0057	Down

The name of compounds, class, VIP, value, and trend of metabolites were shown in the table.