Uncovering the Molecular Mechanism of the Qiang-Xin 1 Formula on Sepsis-Induced Cardiac Dysfunction Based on Systems Pharmacology

Figure 9

Effects of the QX1 formula on the sepsis-induced cardiac dysfunction pathway. (a, b) Western blot analysis of total CaMKII and P-CaMKII protein expression in heart tissues. (c, d) The expression levels of P-AKT and AKT proteins were determined in cardiac tissue. (e, f) Protein levels of ERK1/2, P-ERK1/2, P38, P-P38, JNK, and P-JNK were detected by Western blot. (g, h) Protein levels of TLR4 and NF-κB were detected by Western blot. Data were presented as , and differences between means were compared using one-way ANOVA with Tukey’s multiple comparison test. compared to the sham group, ^#, ^## compared to the CLP group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)