Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4

<div>OMT inhibits oxidative stress and apoptosis in SH-SY5Y cells treated with high glucose. (a) Representative images of Hoechst staining. (b) Percentage of apoptotic cells. (c) Caspase-3 activity. (d) Caspase-3 protein expression levels. (e) Flow cytometry analysis of the annexin V-FITC/PI staining. (f) Quantification of annexin V-FITC/PI staining, showing the percentage of early (annexin V-FITC positive and PI negative) and late (annexin V-FITC positive and PI positive) apoptotic cells. 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OMT: oxymatrine.</div>

Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4 