The Effects of Calcium-β-Hydroxy-β-Methylbutyrate on Aging-Associated Apoptotic Signaling and Muscle Mass and Function in Unloaded but Nonatrophied Extensor Digitorum Longus Muscles of Aged Rats

Figure 2

Muscle and bodyweight. (a) The body weight of water-gavaged and Ca-HMB-gavaged animals are shown after 14 days of hindlimb suspension (HS) or 14 days of HS followed by 14 days of reloading (R). The animals received Ca-HMB or the vehicle (water) daily by gavage, for a total of 21 days (HS Con and HS) or for 32 days (R Con and R). (b) EDL muscle wet weight was obtained in cage control animals for the hindlimb suspension group (HS Con), cage control animals for the recovery group (R Con), and water-treated and Ca-HMB-treated animals after 14 days of hindlimb suspension (HS) or after 14 days of hindlimb suspension followed by 14 days of reloading (R). (c) The ratio of EDL muscle wet weight to body weight was reported. A MANOVA followed by Bonferroni’s post hoc analyses were used to evaluate the differences between the group means. The data are expressed as . ; HS or R vs. control animals for that experimental condition.

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