A Review of Adropin as the Medium of Dialogue between Energy Regulation and Immune Regulation

Figure 1

Infiltration of macrophages in adipose tissues causes chronic inflammation. Adipocytes are able to secrete cytokines such as TNF-α and MCP-1 that attract macrophages and Treg cells, leading to fat inflammation. Adropin regulates the expression of PPAR-γ by activating EK1/2 and AKT pathways, thus promoting the proliferation of 3T3-L1 preadipocytes and inhibiting the differentiation of 3T3-L1 preadipocytes into mature adipocytes and thus reducing fat accumulation and fat inflammation.