Cerebral Mitochondrial Function and Cognitive Performance during Aging: A Longitudinal Study in NMRI Mice
Relative normalized mRNA expression levels of cytochrome c oxidase subunit 5A (a), cAMP response element-binding protein (creb-1) (b), AMP-activated protein kinase (β-AMPK) (c), mitochondrial transcription factor A (Tfam) (d), and brain-derived neurotrophic factor (BDNF) (e) in brain homogenate of 3-, 6-, 12-, 18-, and 24-month-old mice. mRNA expression of 3-month-old control mice is 100%. , with one-way ANOVA and Tukey’s post hoc test with ,,, and against 3-month-old control animals. “A” indicates one-way ANOVA and Tukey’s post hoc test against 6-month-old mice, “B” against 12-month-old mice, and “C” against 18-month-old animals. Results are normalized to the mRNA expression levels of beta 2 microglobulin (B2M) and phosphoglycerate kinase 1 (PGK1).
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