NLRP3 Inflammasome and Inflammatory Diseases

Table 1

Role of NLRP3 inflammasome in disease.

Disease	Responsible factor	Effect	Ref
Aspergillus fumigatus keratitis	NLRP3, caspase-1, and IL-1β	Pannexin 1 channels play important roles in the regulation of progression and leucocyte aggregation during corneal A. fumigatus infection via the NLRP3/caspase-1/IL-1β pathway.	[36]
Stargardt disease type 1	NLRP3, ROS, IL-1β, and IL-18	Aberrant buildup of atRAL promotes the death of RPE cells via NLRP3 inflammasome activation.	[82]
Alzheimer’s disease	NLRP3, caspase-1, and IL-1β	Strongly enhanced the active NLRP3/caspase-1 axis in human mild cognitive impairment and brains with Alzheimer’s disease.	[83]
Atherosclerosis	NLRP3	NLRP3 was overexpressed in aorta of patients with coronary atherosclerosis.	[84]
Atrial fibrillation	NLRP3	The inhibition of NLRP3 as a potential novel AF therapy approach.	[85]
Osteoarthritis	NLRP3, caspase-1, and IL-1β	Inhibition to the release of inflammasome NLRP3 exerts protection on osteoarthritis leading to the downregulation of inflammatory cytokines.	[85]
Cancer	NLRP3, caspase-1, IL-1β, and IL-18	Dysregulation of NLRP3 inflammasome activation is involved in tumor pathogenesis.	[87]